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Also prolactin is increased and responds to external stimuli, including emotional and physical events as well as internal rhythms such as sleep

Cardiovascular (Heart and Blood Vessel) Complications In rare but serious cases, B12 replacement can lead to heart and blood vessel problems: Shortness of breath Peripheral edema (swelling in legs and arms) Rapid weight gain Pulmonary edema (fluid in lungs) Congestive heart failure (heart cannot pump effectively) Blood clots in vessels These complications arise from increased blood volume, thicker blood, and sudden changes in how hard the heart needs to work

Additionally, disc degeneration in OTLFK patients was associated with abnormal sagittal spinal parameters and endplate injury

IV glutathione for cosmetic use lacks published efficacy trials and is now restricted in India (CDSCO, May 2026)