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Overall, ITP-LNP/siBACE1 was more effective at improving behavioral and AD-like pathological features in APP/PS1 mice than compared with the other treatment conditions, reflecting the potential of allosteric targeting for the treatment of disorders associated with deletion of the ectodomain of the target receptor

During embryonic development, oligodendrocyte progenitor cells (OPCs) are specified from neuroepithelial neural stem cells in the spinal cord and the forebrain (Rowitch and Kriegstein, 2010)

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