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Cerebrovascular and bloodbrain barrier impairments in Huntingtons disease: potential implications for its pathophysiology

The smaller final step from 8mg to 12mg (a 50% increase rather than a 100% doubling) reflects the finding that GI tolerability improves at higher doses once the body has already adapted to substantial receptor activation

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Drawing too much or too little medication from a vial means either wasted product or underdosing