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Several randomized controlled trials demonstrated improved cardiovascular outcomes in type 2 diabetics taking GLP-1RAs [2024]

The distinguishing factor clearly lies in the application and dosimetry

Compared to the control group, those using Polyphenon E had reduced levels of the vascular endothelial growth factor (VEGF) from 24 months and significantly lower levels of serum hepatic growth factor (HGF) at 2 months

Summary: Berberine may interact with numerous prescription medications by inhibiting liver enzymes (particularly CYP3A4, CYP2D6, CYP2C9) and P-glycoprotein, potentially altering drug levels and increasing risks of adverse effects or treatment failure