Across these studies, weight loss was consistently greater with semaglutide than with placebo, and the weight loss was associated with improvements in cardiometabolic risk factors including blood pressure, waist circumference, lipid profiles, and inflammatory markers
It names dehydration, electrolyte shifts, and gallstone formation as consequences of rapid weight loss
Last reviewed: June 9, 2026 Last updated: June 9, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations
But you may be able to reduce the side effects by beginning on a lower dose and then slowly increasing the amount you take