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Remarkably, a study by Escribano et al revealed that, when compared with the control group, children with severe AATD showed significantly increased levels of oxidative stress biomarkers and decreased levels of antioxidants, as expressed by lower total and reduced glutathione levels, decreased catalase activity, and increased glutathione peroxidase activity

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These results are not consistent with changes in hepatic CYP2E1 or ALDH1A1 mediating enhanced EtOH metabolism in KO mice under the condition of chronic alcohol consumption