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Currently, key processes leading to neurodegeneration are considered to be oxidative stress, disruption of transition metal homeostasis, and inflammation of the nervous system

doi: 10.1016/j.bbagrm.2009.11.011 32 GloverD.LittleJ

Importantly, diselenide linkages are dual-responsive, as they are susceptible not only to GSH reduction but also to oxidation by reactive oxygen species (ROS), such as hydrogen peroxide [59]