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Glutamine is transported to cells through the transporter SLC1A5 (member of solute carrier family 1 neutral amino acid transporter 5), and glutamate is generated under the catalysis of glutaminase (GLS or GLS2) as one of the raw materials for glutathione synthesis [92]

The ongoing development and increased availability of DNA sequencing technology have uncovered several molecular causes of SLOCA besides spastic paraplegia type 7 and very late-onset Friedreich ataxia

( c ) Body weight time course, ( d ) changes in body weight, fat mass, and fat free mass from day 5 to 26