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A large study using electronic health records from over 100 million US patients found that semaglutide was associated with a significantly lower risk of both first-time and recurring suicidal ideation compared to non-GLP-1 anti-obesity and anti-diabetes medications
These important findings suggest that tesofensine could be a safe and effective option for treating obesity
Lett AM, Lim A, Skinner C, Maurice J, Vergis N, Darzi A et al (2021) Rapid, non-invasive measurement of gastric emptying rate using transcutaneous fluorescence spectroscopy
Phase 2 (Q1 2026) will add additional samples (up to 25,000 patients) and more detailed clinical phenotype data to identify predictive safety and tolerability markers and include further validation and refinement of the efficacy signals including: Phasing of drug therapy and impact on efficacy Prediction of high rebound cohorts Evaluation of potential efficacy in other indications PrecisionLife has developed and validated a world-leading combinatorial analytics platform to identify the drivers underpinning over 60 complex chronic diseases
