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Convenient Weekly Dosing: Administered once per week, GLP-1 therapy is easier to manage than daily medications

Despite these new insights into CV benefits of GLP-1 RAs, questions still remain

Among these are nuclear hormone receptor agonists (e phenoxy)butanoic acid (MK-0533): a novel selective peroxisome proliferator-activated receptor gamma modulator for the treatment of type 2 diabetes mellitus with a reduced potential to increase plasma and extracellular fluid volume

If dose escalation is not tolerated due to side effects (eg, nausea, vomiting, diarrhea, constipation), the increase in dose can be delayed by another four weeks