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More research is needed to understand the mechanisms through which semaglutide produces these early clinical benefits, but they may include the drugs positive effects on reducing inflammation, blood sugar, blood pressure, direct effects on the heart and blood vessels, early dietary changes, or an interaction among these or other responses. The Select trial is a randomised, double-blind trial looking at semaglutide 2.4mg versus placebo for the prevention of heart attacks, strokes and early death in people with established cardiovascular disease who are overweight or have obesity

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The details of the analysis performed to obtain the MSD of the beads are described elsewhere ( 64 )