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Lichen planus CDC | James Heilman, MD / Wikimedia Commons What it looks like : Purplish lesions on the inner arms, legs, wrists, or ankles can signify lichen planus, a skin rash triggered by an overreaction of the immune system

Yes, it's usually a normal reaction

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Heres what the published research actually found, mechanism by mechanism, with the limitations of each finding stated alongside it