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Abstract The interaction between the upper gastrointestinal tract and the endocrine system is important in the regulation of metabolism and of weight

In addition, we constructed z-unit-based composite scores indicating autonomic symptoms, sleep problems, fatigue, GIS symptoms, and cognitive symptoms using all relevant HAMD, HAMA, and FF items (z transformed)

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While Metformin improves insulin sensitivity and helps control appetite, GLP-1 medications (like semaglutide or tirzepatide) slow digestion and enhance feelings of fullness