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found that liraglutide, an GLP-1R agonists, reduces the activated microglia load in the cortex and dentate gyrus region of hippocampus, and the activated astrocyte load in the cortex

Abstract The glucagon-like peptide-1 (GLP-1) receptor, known as GLP-1R, is a vital component of the G protein-coupled receptor (GPCR) family and is found primarily on the surfaces of various cell types within the human body

The biological activity can be assessed using a colorimetric bioassay consisting of the engineered cell line HEK-Blue GLP-1 expressing the GLP-1R together with a CREB-inducible SEAP reporter gene (see figure)