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Access this article Similar content being viewed by others Abbreviations ALS: acid labile subunit BMP: bone morphogenic protein COJ: chondro-osseous junction FDA: Food and Drug Administration FGF: fibroblast growth factor GH: growth hormone GHR/: growth hormone receptor knockout GnRH: gonadotropin releasing hormone GP: growth plate HZ: hypertrophic zone of growth plate cartilage IGF-1: insulin-like growth factor 1 IGF-1R: insulin-like growth factor 1 receptor IGF2: insulin-like growth factor 2 IGFBP: insulin-like growth factor binding protein Ihh: Indian hedgehog LID: liver IGF-1-deficient LLD: limb length discrepancy MAPK: mitogen-activated protein kinase MMP-9: matrix metalloproteinase 9 MPM: multiphoton microscopy PTHrP: parathyroid hormone-related protein PZ: proliferative zone of growth plate cartilage RZ: reserve zone of growth plate cartilage T3: triiodothyronine TKI: tyrosine kinase inhibitors TR1: thyroid hormone receptor alpha 1 TR: thyroid hormone receptor beta VEGF: vascular endothelial growth factor WISP3: Wnt-induced secreted protein 3 Wnt: wingless/integrated Zn: zinc References Papers of particular interest, published recently, have been highlighted as: Of major importance Farnum CE

It seems increasingly clear that during these sensitive periods, special plasticity mechanisms that have a much smaller prevalence during adulthood are potentiated

Common early complaints can include: Nausea or a mildly unsettled stomach Feeling full after smaller meals Reduced interest in food Bloating or belching Indigestion or heartburn Diarrhea Constipation Abdominal discomfort Fatigue These symptoms overlap with adverse reactions listed in current prescribing information for Wegovy and Zepbound

Eliassen LT, Berge G, Leknessund A, Wikman M, R