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In the mouse duodenal myenteric plexus, 18% of GLP-2R+ are nNOS+, 10% are vasoactive intestinal polypeptide (VIP)+, 71% are choline-acetyltransferase (ChAT)+, and 27% are SP+ (Cinci et al., 2011) (Figure 1 and Table 3)
Its more common in people with certain conditions like diabetes, high blood pressure, and sleep apnea, per Brigham and Womens Hospital
This is why retatrutide dosing must be carefully managed, especially in people with insulin resistance or type 2 diabetes
Take in the evening as it has mild relaxing effects
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