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In this perspective, in order to better elucidate the results of clinical trials, different meta-analyses examined the effects of NAC on COPD, using, as criteria for evaluation, the total number of exacerbations, number of patients with at least one exacerbation, and decline in FEV 1 [56,57]

Activation of genes encoding antioxidant enzymes such as catalases and GST1 was detected in the tissue surrounding the initial infection site (Schenk et al., 2000)

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