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Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease

Accessed 11/21/2012

Therapeutic strategy focusing on the ferroptosis pathway SLC7A11, a molecule that protects cancer cells from ferroptosis-induced cell death, is overexpressed in different types of cancers, including ovarian cancer, lung cancer, triple-negative breast cancer, PDAC, renal cell carcinoma, liver cancer, and glioma, and it is associated with aggressive phenotypes and poor prognosis [16,46,89]

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