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A small pilot study published in the European Journal of Clinical Nutrition gave healthy adults 500mg or 1000mg of oral liposomal glutathione daily for a month and measured meaningful jumps in natural killer cell activity and lymphocyte proliferation within two weeks, alongside up to a 40% rise in whole-blood glutathione (Sinha et al., 2018)

SAM supplies methyl groups for hundreds of reactions involving DNA, phospholipids, neurotransmitter metabolism, creatine synthesis, hormone metabolism and selected detoxification reactions

It is regulated by apoptosis-related genes, such as Bcl-2, P53, cytochrome C (Cyt C), APAF-1, and the caspase family proteins [7]