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The inclusion of ongoing studies (summarizing their characteristics and including them in the synthesis of evidence) and unpublished trials is recommended by methodological guidelines and stated by Cochrane Handbook [15]

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doi: 10.3389/fnins.2024.1467333 Received 19 July 2024 Accepted 20 September 2024 Published 02 October 2024 Volume 18 - 2024 Edited by Iliya Lefterov, University of Pittsburgh, United States Reviewed by Ankit Seth, Augusta University, United States W

Second, the trial reported results under more than one statistical estimand