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The significant impact of GLP-1RAs on calcium homeostasis and cellular behavior is also confirmed in other cell types apart from RGCs

Lifestyle changes in the developed regions of the world and the absence of effective preventive screening programs and healthcare access in some less-developed regions are expected to further increase cancer-related morbidity and mortality in the future (Sung et al., 2021)

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In a mouse model of MS, UA can penetrate the compromised blood-brain barrier (BBB), block ONOO -mediated tyrosine nitration, and contribute to the containment of the central nerve system (CNS) pathology [44]