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In the presence of FDX1 and adequate copper, cuproptosis is induced by delivering extracellular Cu into cells [56]

Interestingly, Glp1r was not produced by epithelial cells but rather by clusters of small cells primarily located within the lamina propria, consistent with previous findings 70

These drugs are synthetic ligands for the transcription factor PPAR, a member of a superfamily of nuclear receptors including thyroid and steroid receptors

doi: 10.3389/fped.2023.1263836 Received 20 July 2023 Accepted 21 August 2023 Published 12 September 2023 Volume 11 - 2023 Edited by Paul Henderson, University of Edinburgh, United Kingdom Reviewed by Tudor Lucian Pop, University of Medicine and Pharmacy Iuliu Hatieganu, Romania Bin Wang, Shenzhen Childrens Hospital, China Updates Copyright 2023 Jiachen, Paul Kwong Hang, Kenneth Kak Yuen and Vincent Chi Hang