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Carnitine transporter mutations in Crohn's disease consists of missense mutation(s) in the gene coding plasma membrane transporter OCTN1 (SLC22A4) and/or mutation(s) in the promoter of the gene encoding OCTN2 (SLC22A5) [14, 35]

Sample size Sample size was calculated using the method of Riley et al , assuming a Cox-Snell R 2 of 0.11 (based on prevalence of 50%60% for the primary outcomes), 12 potential predictors and assuming a shrinkage factor of no less than 0.9 to minimise model overfitting.13 Minimum sample size was 824840

Detoxification: Supports the skins natural detoxification process, promoting a clearer and healthier complexion

GL and HS participated in writing and project management