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Betaine improved methylation capacity by increasing SAM/SAH ratio and normalized the gene expression of key enzymes accountable for one-carbon metabolism (e.g., BHMT, GNMT, and MGAT) associated with the regulation of fat metabolism in the liver ( Anomaly in gene expression in hepatocytes due to aberrant DNA methylation leads to the disorder of NAFLD

It is a metabolic stressor one that actively worsens insulin sensitivity, elevates cortisol, disrupts GH secretion, upregulates hunger hormones, and promotes visceral fat accumulation

Mikoaj Filarski, Magorzata Majdaniec ul

Dose-Response Patterns Phase 1/2 trials tested CJC-1295 with DAC at single doses ranging from 30-250 mcg/kg (PMID 16352683)