As a new type of topical dosage form, it significantly accelerates the healing of burns, trauma, diabetic ulcers and inflammatory bowel disease through multiple mechanisms such as promoting angiogenesis, inhibiting inflammatory responses, accelerating cell proliferation and antioxidation and antiapoptosis
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Shared decision-making incorporating patient preferences, realistic expectations, and transparent discussion of evidence limitations is essential before proceeding with combination therapy
Besides well-known oxidants or electrophiles, such as H 2 O 2 , 4-hydroxynonenal, and diethyl maleate (DEM), which also possess cytotoxicity, only few Nrf2 activators have been found to be useful in clinical trials (Sun et al