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As mentioned in the Introduction, both lowered SpO2 and increased body temperature are part of the immune-inflammatory response, predict critical illness and death, and are manifestations of the infectious-immune-inflammatory core of acute COVID-19 [94]

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More broadly, they challenge the traditional separation between metabolic and psychiatric disease, suggesting peripheral metabolic signals can influence central processes such as motivation and behavior

doi: 10.3389/fimmu.2024.1470283 21 LarssonSCBurgessS