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[121] Age is also a contributing factor: elderly individuals are often achlorhydric due to reduced parietal cell function in the stomach, increasing their risk of vitamin B 12 deficiency

Functioning as a potent exercise mimetic, this small-molecule compound enhances mitochondrial function, fatty acid oxidation, and oxidative muscle fiber composition, thereby improving exercise endurance, cardiac metabolic efficiency, and systemic energy expenditure without increasing food intake 1-4 .

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Structured programs incorporating reduced-calorie diets (typically 500-750 kcal/day deficit), increased physical activity (150 minutes of moderate-intensity exercise weekly for weight loss