A combined effect that is bigger than just decreasing calories is thought to be at play when looking at the effects of activating the GLP-1 receptor.[ref] In overweight adults aged 45+, a 4-year-long study using semaglutide for weight loss also prevented HbA1c from rising over time, which was seen in the placebo arm
GLP-1 and GLP-1 RA (such as Exenatide and Liraglutide) were shown to have an anti-inflammatory action by reducing monocyte adhesion and macrophage accumulation, thus stabilizing atherosclerotic plaque, and slowing atherosclerosis in animal models [47,48,49]
They include type 2 diabetes, obesity, cardiovascular event risk reduction, obstructive sleep apnea, chronic kidney disease, and metabolic dysfunction-associated steatotic liver disease
Learn more about GLP-1s and other diabetes medications here: Related New Articles See All GLP-1 and Incretin Drugs News You Asked the Internet About GLP-1s: Here's What It Couldn't Tell You A guide to deciding, starting, affording, and living with the most talked-about diabetes medications in a generation
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