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Holly Wyatt: And I'm Holly Wyatt

10.1056/NEJMoa2206038 36 KadowakiT.NambaM.ImaokaT.YamamuraA.GotoW.BoardmanM

We now have randomized controlled trial data from 2024 and a prospective substudy from 2025 documenting measurable changes in both

However, the oncological significance of GCG signaling remains insufficiently defined, and the currently available evidence does not support a uniform conclusion that GCGR activation exerts a direct antitumor effect (61)