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Moreover, in a xenograft mammary 4T1 tumor model, it has been demonstrated that the concurrent administration of BAPN and the enzyme-responsive drug (NQO1-SN38), designed to target breast tumors with the topoisomerase I inhibitor SN38, results in a cooperative reduction in tumor growth [100]

Moller L, Dalman L, Norrelund H, Billestrup N, Frystyk J, Moller N, et al

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In other words, metformin isn't just a glucose-lowering drugit's a top-down rewiring agent for gut nutrient sensing and hormone modulation, which likely underlies the benefits observed across so many organ systems