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The results showed that Th1 cells polarized microglia towards high expression of INF response related genes ( Irf7 and Stat1 ), which further exacerbated the immune response in the later stages of neurodegenerative diseases

Ultrathin sections (with silver to gray interference) were cut using a diamond knife (Diatome, Biel, Switzerland), mounted on Formvar-coated single-slot grids and then counterstained with 3% uranyl acetate and then with 0.2% lead citrate (Sigma-Aldrich)

Frankfurt am Main: Senckenberg Forschungsinstitut