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Additionally, anyone with known hypersensitivity to semaglutide or its ingredients should not take this medication due to the possibility of severe allergic reactions

30 In adolescents with obesity, semaglutide 2.4 mg once weekly led to weight loss similar to that observed in adults (a 16.1% mean reduction in BMI from baseline vs 0.6% with placebo at 68 weeks), along with improvements in cardiometabolic risk factors such as waist circumference, glycated haemoglobin (HbA 1c ), LDL-cholesterol, triglyceride and alanine transaminase levels

Common gastrointestinal side effects (nausea, vomiting, diarrhoea) may compound existing MS-related bowel dysfunction and require careful monitoring

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