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This peroxidation promotes the interaction between DPP4 and nicotinamide adenine dinucleotide phosphate oxidase 1 (NOX1), resulting in the formation of the NOX1DPP4 complex, which mediates plasma membrane lipid peroxidation and ferroptosis (Xie et al., 2017

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Chronic alcohol use activates microglia, leading to neuroinflammation characterized by the release of pro-inflammatory cytokines, such as TNF-, IL-1, and IL-6 (Tiwari and Chopra 2012)