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Hydrolysis is the common degradation pathway of carboxylic acid derivatives, such as esters, amides, lactams, lactones, imides, and oximes (Figure 7.7)

In addition to the physiological role of receptor-mediated transcytosis, such as the brain delivery of leptin via leptin receptors (35), the phenomenon has been harnessed for the delivery of drugs across the BBB and is considered as one of the most promising brain drug delivery strategies