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Key effects include: Stimulation of collagen I, III, and V synthesis Increased elastin production Enhanced glycosaminoglycan (GAG) synthesis Promotion of blood vessel growth (angiogenesis) Anti-inflammatory gene modulation Superoxide dismutase upregulation (antioxidant protection) Hair follicle enlargement and growth stimulation How Semaglutide in This Context Semaglutide is a GLP-1 receptor agonist that produces weight loss primarily through appetite suppression and improved metabolic function

Low LH, low estradiol, and low-normal T3 in the presence of normal TSH suggest functional hypothalamic suppression secondary to energy deficit