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Circulation 2021;143:1157-72.ArticlePubMedPMC 7

Inhibition of angiogenesis To fuel their rapid growth, invasive tumors must develop new blood vessels by a process known as angiogenesis

To put 16.8% in context: for a person weighing 220 pounds, that's nearly 37 pounds lost, from a drug whose primary focus in this trial was treating diabetes , not obesity

In a briefing document published ahead of the panel meeting, the FDA once again highlighted the issue of acute kidney injury, which occurred more often in patients with the implant than controls, along with major adverse cardiovascular events (MACE), side effects and mortality data that were unfavourable to the implant