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The two GLP-1 receptor agonists covered in this guide have common side effects nausea, diarrhea, and vomiting but in the 2021 study weve referenced, semaglutide exhibited up to a 5% lower risk of nausea, 4% of diarrhea, and 2% of vomiting.3 Its lower side effect risk compared to tirzepatide is slight but clear