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Approved in 1964 for the management of hypertension, propranolol is now used for a wide range of cardiovascular diseases, including ischemic heart disease, angina pectoris, arrhythmias, and myocardial infarction, as well as non cardiovascular conditions, including migraine, tremors and anxiety

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This trial showed that patients who received semaglutide had a 26% lower risk of the primary composite outcome than the placebo group, principally driven by a significant 39% reduction in nonfatal stroke, with no significant difference in the rate of cardiovascular death

To investigate a possible metabolic signature in the PBH group, we performed untargeted metabolomics