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Common Sleep Issues Reported During GLP-1 Treatment Patients on semaglutide describe several patterns: delayed sleep onset (taking longer to fall asleep), early morning waking (waking before desired time), and lighter overall sleep quality

Additionally, the GLP-1R/glucose-dependent insulinotropic polypeptide receptor (GIPR) dual agonist tirzepatide can induce weight loss of 10%20%, and the results of the ongoing SURPASS-CVOT trial may provide more clarity on whether weight loss itself is an independent driver of CV protection (74)

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