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Molecular dynamics simulations Molecular dynamics simulations have been performed using the AMBER ff19SB force field 57 and the solvent molecules were represented as OPC water molecules 58

Cell migration assay The in vitro scratch assay and transwell assay were used to study the migration of BMSCs

Excluded OPPS Services and Hospitals Section 1833(t)(1)(B)(i) of the Act authorizes the Secretary to designate the hospital outpatient services that are paid under the OPPS

The included preclinical studies demonstrated consistently positive effects across diverse injury models including tendon rupture, ligament tears, muscle injuries, bone fractures, and combined soft tissue trauma