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Tab 2: Mutations found in individual clones in second-generation evolution

doi: 10.1038/s41531-024-00724-z 36

Additional refinements to its structure to limit both phase 1 and phase 2 hepatic metabolism and first pass clearance, to reduce metabolism by gastric enzymes and enhance oral bioavailability, and to diminish polar surface area and overall size to facilitate BBB penetrability are currently in progress