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The struggle is so pronounced that it raises a fundamental question about clinical autonomy

GIP has been shown to enhance GLP-1 production and insulin secretion and has no effect on gastric emptying [13]

Ultimately, expanding the indications for GLP1RA, and possibly dual agonists, beyond diabetes and obesity could improve health and prolong healthy aging in a more general population

In animal studies, this drug not only directly activates GLP-1 receptors in the hypothalamus and brainstem but also indirectly modulates neuronal circuits in other regions involved in eating behavior, such as the lateral parabrachial nucleus