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FLOW trial participants with type 2 diabetes and chronic kidney disease were stratified by baseline SGLT2i use ( N = 550) or no use ( N = 2,983) and randomized to semaglutide/placebo

In healthy humans, GIP has a circulating half-life of 7 min (Meier et al., 2004b), GLP-1 has a circulating half-life of 12 min (Deacon et al., 1995b), and GLP-2 has a circulating half-life of 7 min (Drucker et al., 1997