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GLP-1 Weight Loss Medications: The Good, the Bad, and the Ugly And What Theyre Really Doing to Your Muscle, Metabolism, and Long-Term Results December 19, 2025 GLP-1 Weight Loss Medications: The Good, the Bad, and the Ugly And What Theyre Really Doing to Your Muscle, Metabolism, and Long-Term Results Photo Credit: Shutterstock GLP-1 weight loss medications such as Ozempic, Wegovy, Mounjaro, and Zepbound have exploded in popularity over the last few years

In preclinical hepatocyte and rodent models, the compound is studied for its effects on lipogenesis, -oxidation enzymes, and de-novo lipogenic transcription factors such as SREBP-1c and ChREBP

Policy Endocrinologist Anira Iqbal, MD, explains why GLP-1s work best the longer you take them

Brand-name Wegovy can cost over $1,300 per month without insurance