Once within the hepatocyte mitochondria, unconjugated bilirubin is transported with ligandin (Y protein or glutathione-S-transferase A) or other proteins (e.g
We believe that significant efforts should be put into investigating in greater detail the pathways shared by eryptosis and erythronecroptosis, like caspase-8, ROS signaling, Fas/FasL signaling, to collect more evidence on the interplay between these erythrocyte-specific RCDs
The following exclusion criteria were applied: 1) Laugier-Hunziker syndrome, neurofibromatosis, McCune-Albright syndrome, Peutz-Jeghers syndrome, LAMB (lentigines, atrial myxomas, mucocutaneous myxomas, and blue nevi) syndrome, and the associated Carney syndrome
However, talking therapies that reduce stress and anxiety, vitamin D3 supplementation, correction of intestinal dysbiosis and treatment of any chronic infection should also be considered