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In extreme cases of intestinal obstruction, the GLP-1 patient may require the use of an ileostomy bag or a colostomy bag for the rest of their life

Difficulty falling asleep (sleep onset insomnia) has been reported anecdotally by some patients, particularly during the initial weeks of treatment or following dose escalations

The dramatic results patients show off in countless before-and-after photos have made them wildly popular

Coughlins closing line on the GLP-1 category captured the strategic logic: Were not interested in kind of me-too entries. With Entresto facing generic erosion and Leqvio soon confronting oral PCSK9 competition from Mercks Enlicitide, Novartis is staking its cardiovascular future on mechanisms that sit adjacent to not inside the metabolic pathway that everyone else is chasing