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Moreover, the signaling pathways regulating ferroptosis exist in as yet unclear crosstalk with many classical cell signaling pathways, such as the energy metabolism pathway with the PI3K-AKT-mTOR pathway (63)
doi: 10.1186/s12967-022-03328-4 78 SuYYuanDChenDGNgRHWangKChoiJet al
When ligands (such as IS, IAA, and kynurenine) bind to AhR, AhR is released from the chaperone protein complex and translocates to the nucleus, where it heterodimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT), then binds to xenobiotic response elements (XRE) or dioxin response elements (DRE) to induce downstream target gene transcription (120)
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