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The dose ranges studied spanned from 0.25 mg to 54 mg, allowing for assessment of dose-response relationships in adverse effect profiles

Beyond structural and sensory-motor roles, numerical studies have indicated a propulsive function for them as well, presenting the hypothesis that chemical energy released by a rapidly disassembling microtubule can be converted into useful work needed to generate the large mechanical forces that propel chromosomes during cell replication [133]

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When sponsors build study-specific tech stacks that sit outside an investigator's normal standard-of-care environment, investigators cannot train or supervise their own staff within familiar workflows