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Patients on combination therapy should monitor blood glucose levels regularly and discuss potential dose reductions of insulin or sulfonylureas with their healthcare provider during tirzepatide initiation and dose escalation
Key weight loss results [3] : Participants taking oral semaglutide lost about 16.6% of their starting body weight at 64 weeks (with full adherence) The placebo group lost only about 2.2% 28% of people lost 20% or more of their starting weight All participants followed a reducedcalorie diet and increased physical activity For comparison, onceweekly Wegovy 2.4 mg injections show about 16.9% mean weight loss in similar trials, suggesting that average weight loss is broadly comparable between the tablet and injection [4]
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The data are genuinely impressive
Endocrinology (1962) 70:26771
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