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In the randomized ACTIVE trial in older adults, about ten hours of it lowered the risk of dementia by roughly 29 percent over ten years, and a 20-year follow-up found that the speed arm with booster sessions was the only training type with a lasting reduction in dementia diagnoses, and NeuroAge offers a training game inspired by it

The pathway analysis by KEGG on differentially expressed proteins suggested that the significantly affected pathways were steroid hormone biosynthesis, propanoate metabolism, systemic lupus erythematosus, non-alcoholic fatty liver disease (NAFLD), fatty acid degradation, fatty acid metabolism, citrate cycle (TCA cycle), carbon metabolism, fat digestion and absorption, Parkinsons disease (PD), oxidative phosphorylation, ubiquinone and other terpenoid-quinone biosynthesis, alcoholism (Fig

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